Comparative analyses of the Conserved Oligomeric Golgi (COG) complex in vertebrates |
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| Authors: | Rita Quental Luísa Azevedo Rune Matthiesen António Amorim |
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| Institution: | (1) IPATIMUP -Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal;(2) Faculty of Sciences, University of Porto, Porto, Portugal |
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| Abstract: | Background The Conserved Oligomeric Golgi (COG) complex is an eight-subunit assembly that localizes peripherally to Golgi membranes and
is involved in retrograde vesicular trafficking. COG subunits are organized in two heterotrimeric groups, Cog2, -3, -4 and
Cog5, -6, -7, linked by a dimeric group formed by Cog1 and Cog8. Dysfunction of COG complex in humans has been associated
with new forms of Congenital Disorders of Glycosylation (CDG), therefore highlighting its essential role. In the present study,
we intended to gain further insights into the evolution of COG subunits in vertebrates, using comparative analyses of all
eight COG proteins. |
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