Orchestrating nuclear functions: ubiquitin sets the rhythm |
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| Authors: | Bach Ingolf Ostendorff Heather P |
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| Affiliation: | 1. Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, PR China;2. Yichang Humanwell Pharmaceutical Co., Ltd, Yichang, 443005, PR China;3. School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan, 430205, PR China;1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, Baltimore, Maryland, USA;2. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Hunan, China;1. Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea;2. Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA;3. Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea |
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| Abstract: | The nucleus of the eukaryotic cell must carry out many functions simultaneously. These tasks include ensuring that the cell is continuously supplied with an appropriate, changing set of proteins on its way through cell divisions and differentiation. During these processes, the integrity of the genetic material must be maintained against a constant onslaught of damaging physiological and environmental factors. Fulfilling these complex tasks requires the dynamic integration and synchronization of different nuclear functions. Protein modification by ubiquitin is proving to be a crucial tool for nuclear functioning, and is emerging as a decisive mechanism that enables the concerted regulation of nuclear pathways. |
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