Determination of the relative and absolute stereochemistry of a potent and α1A-selective adrenoceptor antagonist |
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Authors: | Bharat Lagu John M Wetzel Carlos Forray Michael A Patane Mark G Bock |
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Abstract: | The binding affinities and selectivities of antagonists Figure 1 and Scheme 2 for the α1A-adrenoceptor are dependent on the stereochemical orientation of the groups at the C-4 and C-5 positions of the oxazolidinone ring. The unambiguous assignment of the relative and absolute configurations of the diastereomers of SNAP 7915 (Figure 1 and Scheme 2) is reported. |
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