A statistical model for multidimensional irreversible electroporation cell death in tissue |
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| Authors: | Alex Golberg Boris Rubinsky |
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| Institution: | (1) Center for Bioengineering in the Service of Humanity and Society, School of Computer Science and Engineering, Hebrew University of Jerusalem, Givat Ram, 91904 Jerusalem, Israel;(2) Department of Mechanical Engineering, Graduate Program in Biophysics, University of California at Berkeley, 84720 Berkeley, CA, USA |
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| Abstract: | Background Irreversible electroporation (IRE) is a minimally invasive tissue ablation technique which utilizes electric pulses delivered
by electrodes to a targeted area of tissue to produce high amplitude electric fields, thus inducing irreversible damage to
the cell membrane lipid bilayer. An important application of this technique is for cancer tissue ablation. Mathematical modelling
is considered important in IRE treatment planning. In the past, IRE mathematical modelling used a deterministic single value
for the amplitude of the electric field required for causing cell death. However, tissue, particularly cancerous tissue, is
comprised of a population of different cells of different sizes and orientations, which in conventional IRE are exposed to
complex electric fields; therefore, using a deterministic single value is overly simplistic. |
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