Pathogenetic consequences of cytomegalovirus-host co-evolution |
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Authors: | Gerardo Abenes Fenyong Liu |
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Institution: | Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720, USA |
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Abstract: | Co-evolution has been shown to result in an adaptive reciprocal modification in the respective behaviors of interacting populations over time.In the case of host-parasite co-evolution,the adaptive behavior is most evident from the reciprocal change in fitness of host and parasite-manifested in terms of pathogen survival versus host resistance.Cytomegaloviruses and their hosts represent a pairing of populations that has co-evolved over hundreds of years.This review explores the pathogenetic consequences emerging from the behavioral changes caused by co-evolutionary forces on the virus and its host. |
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Keywords: | Cytomegalovirus Co-evolution Pathogenesis |
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