Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents |
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| Authors: | Bhat B A Dhar K L Puri S C Saxena A K Shanmugavel M Qazi G N |
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| Institution: | Division of Natural Product Chemistry, Regional Research Laboratory (CSIR) Jammu 180001, India. |
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| Abstract: | A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 93 compounds screened, 8 compounds, 1s, 3i,j,n, 4i,j,n and 4s, showed marked activity. Compounds 4j,n and 4s were found to be the most promising in this study. SAR is also discussed. |
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