A genome-wide survey of alternative translational initiation events in <Emphasis Type="Italic">Homo sapiens</Emphasis> |
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Authors: | Zhang Jing Cai Jun Li YanDa |
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Institution: | 1. Bioinformatics Division, TNLIST and Department of Automation, Tsinghua University, Beijing 100084, China 2. Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801 ,USA |
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Abstract: | Alternative translational initiation is an important mechanism to increase the diversity of gene products. Although some of
alternative translational initiation events have been reported, such information remains anecdotal and does not allow for
any generalizations. The number of the known alternative translational initiation genes is so few that we know little about
its mechanism. There is a great demand to discover more alternative translational initiation genes. However, it is arduously
time-consuming to discover novel alternative translational initiation genes by the experimental method. Therefore we systematically
analyzed protein sequences available in public database and predicted 1237 protein clusters as potential alternative translational
initiation events. We concluded that about 8%–10% of human genes have alternative translational initiation sites. The results
significantly increased the number of alternative translation initiation events and indicated that alternative translation
initiation is an important and general regulation mechanism in the cellular process. |
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Keywords: | genome-wide alternative translation initiation Homo sapiens bioinformatics |
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