Synthesis of N-protected peptide alcohols catalyzed by subtilisin or alpha-chymotrypsin in organic solvents |
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Authors: | Liu Ping Tian Gui-Ling Lo Wai-Hung Lee Kin-Sing Ye Yun-Hua |
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Affiliation: | Ministry of Education, Department of Chemistry, Peking University, Beijing, P R, China. |
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Abstract: | A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or alpha-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied. |
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