Effect of dietary essential fatty acid deficiency on Ca(2+)-ATPase activity in microsomal fraction of rat submandibular gland. |
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Authors: | H Yokoyama R Matsukawa |
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Institution: | Department of Biochemistry, Nihon University School of Dentistry at Matsudo, Chiba, Japan. |
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Abstract: | 1. The effect of dietary essential fatty acid (EFA) deficiency on Ca(2+)-ATPase activity of rat submandibular gland microsomal fraction was studied. 2. The specific activity of Ca(2+)-ATPase per milligram of microsomal protein was depressed about 35% in rats fed the EFA-deficient diet as compared with that in those fed the control diet. 3. Lineweaver-Burk plots for Ca(2+)-ATPase activity showed no significant differences in Km values for Ca2+ and ATP, but the Vmax was decreased in the EFA-deficient rats. 4. The above results suggest that depression of the Ca(2+)-ATPase activity in rats fed the EFA-deficient diet is probably due to the decrease in the Vmax of the enzyme. |
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