The expression of CD 15 antigen on myeloid leukaemia cells--a new prognostic index for complete remission and for survival |
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| Authors: | J Ho?owiecki D Lutz S Krzemień V Schranz K Jagoda B Ho?owiecka F Graf G Kelenyi V Callea M Brugiatelli |
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| Institution: | International Society of Chemo-Immuntherapy Cooperative Group Vienna, Austria. |
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| Abstract: | 377 untreated acute leukaemia patients were categorized according to FAB and cytochemical criterials and simultaneously phenotyped with the use of 6-21 monoclonal antibodies (MoAb) of VI series (W. Knapp, Vienna). The leukaemia phenotype was compared with the patients outcome after treatment. In adult ANLL patients a positive relationships was proved statistically between the expression of the CD 15 cell differentiation antigen on leukaemic blasts and the CR rate (p less than 0.01, chi 2 test). Also a comparison of the Kaplan-Meier survival curves revealed that the CD 15 positive group of ANLL patients has a better outcome than the CD 15 negative one (p less than 0.01, by Wilcoxon and Log-rank tests). Thus, examination of cell differentiation antigens could be a useful addition to existing risk assignment in acute leukaemia. |
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