Zinc depletion suppresses tumor growth in mice |
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Authors: | Atsüshi Takeda Kazühiko Goto Shoji Okada |
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Institution: | (1) Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, 422 Shizuoka, Japan |
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Abstract: | The hypothesis that in tumor-bearing animals an increase of host hepatic zinc metallothionein (Zn-MT) causes a restriction
of zinc in the tumor tissue was studied.
Three types of tumors were induced in laboratory mice by cell transplant. Tumor growth appears to be inhibited under zinc-deficient
conditions, even in cases where zinc deficiency was started after tumor cell transplant.
The survival times of tumor-bearing mice were prolonged by administration of cadmium chloride, which induces the synthesis
of a combined zinc-cadmium metallothionein derivative in the host liver, but not in the tumor tissue, leading to an increase
of hepatic zinc in the treated animals. The uptake of65Zn by the liver of Cd-treated, tumor bearing mice was significantly higher than that of controls whereas uptake of65Zn by tumor cells was significantly higher in controls than in the treated animals.
These results suggest that restriction of zinc intake suppresses tumor growth. |
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Keywords: | Cadmium chloride cadmium-zinc metallothionein tumor growth zinc metallothionein zinc restriction zinc uptake |
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