Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression |
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Authors: | Cedeno-Laurent Filiberto Opperman Matthew Barthel Steven R Kuchroo Vijay K Dimitroff Charles J |
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Affiliation: | Department of Dermatology, Brigham and Women's Hospital, Boston, MA 02115, USA. |
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Abstract: | Galectin-1 (Gal-1), a β-galactoside-binding protein, can alter fate and effector function of Th cells; however, little is known about how Gal-1 induces Th cell differentiation. In this article, we show that both uncommitted and polarized Th cells bound by Gal-1 expressed an immunoregulatory signature defined by IL-10. IL-10 synthesis was stimulated by direct Gal-1 engagement to cell surface glycoproteins, principally CD45, on activated Th cells and enhanced by IL-21 expression through the c-Maf/aryl hydrocarbon receptor pathway, independent of APCs. Gal-1-induced IL-10(+) T cells efficiently suppressed T cell proliferation and T cell-mediated inflammation and promoted the establishment of cancer immune-privileged sites. Collectively, these findings show how Gal-1 functions as a major glycome determinant regulating Th cell development, inflammation, and tumor immunity. |
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