|
|||||
|
|
Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors |
|
| Authors: | Yeh Vince S C Patel Jyoti R Yong Hong Kurukulasuriya Ravi Fung Steven Monzon Katina Chiou William Wang Jiahong Stolarik Deanne Imade Hovis Beno David Brune Michael Jacobson Peer Sham Hing Link J T |
| Institution: | Metabolic Disease Research, Abbott Laboratories, 100 Abbott Park Road, AP-10,304B, Abbott Park, IL 60064, USA. vince.yeh@abbott.com |
| Abstract: | A series of metabolically stable adamantane amide 11beta-HSD1 inhibitors have been synthesized and biologically evaluated. These compounds exhibit excellent HSD1 potency and HSD2 selectivity and good pharmacokinetic and pharmacodynamic profiles. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |