High Progesterone Receptor Expression in Prostate Cancer Is Associated with Clinical Failure |
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| Authors: | Thea Grindstad Sigve Andersen Samer Al-Saad Tom Donnem Yury Kiselev Christian Nordahl Melb?-J?rgensen Kaja Skjefstad Lill-Tove Busund Roy M. Bremnes Elin Richardsen |
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| Affiliation: | 1Dept. of Medical Biology, UiT - The Arctic University of Norway, Tromso, Norway;2Dept. of Clinical Medicine, UiT - The Arctic University of Norway, Tromso, Norway;3Dept. of Oncology, University Hospital of North Norway, Tromso, Norway;4Dept. of Clinical Pathology, University Hospital of North Norway, Tromso, Norway;5Dept. of Pharmacy, UiT—The Arctic University of Norway, Tromso, Norway;Innsbruck Medical University, AUSTRIA |
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| Abstract: | BackgroundProstate cancer is a highly heterogeneous disease and one of the leading causes of mortality in developed countries. Specific prognostic and predictive markers for prostate cancer patients are still lacking. A causal relationship between androgens and the development of prostate cancer is generally considered biologically plausible, but androgens are not the sole effector in the complexity of prostate carcinogenesis. The aim of this study was to evaluate the prognostic significance of progesterone receptor in tumor tissue of T1-3N0 prostate cancer patients undergoing prostatectomy.MethodsTissue microarrays from 535 patients with prostate cancer were constructed. Duplicate cores of tumor cells and tumor stromal tissue from each resected specimen were extracted. Immunohistochemistry was used to evaluate the in-situ expression of progesterone receptor.ResultsIn univariate analyses, high tumor cell density (p = 0.006) and high tumor stromal cell density level (p = 0.045) of progesterone receptor were both significantly associated with tumor progression and clinical failure. In multivariate analysis, progesterone receptor expression in tumor cells was an independent negative prognostic factor for clinical failure (HR: 2.5, 95% CI: 1.2–5.2, p = 0.012).ConclusionHigh progesterone receptor density in tumor cells of the prostate cancer tumor is an independent negative prognostic factor for clinical failure. |
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