Mise au point et validation d’un fantôme spécifique pour assurer le suivi des mesures quantitatives en tomographie par émission de positons |
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| Authors: | C Monnet F Camus L Modolo F Bochud A Bischof Delaloye J O Prior F R Verdun |
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| Institution: | 1. Institut universitaire de radiophysique appliquée (IRA), centre hospitalier universitaire vaudois (CHUV), université de Lausanne (UNIL), 1007 Lausanne, Suisse;2. Département de médecine nucléaire, centre hospitalier universitaire vaudois (CHUV), université de Lausanne (UNIL), 1011 Lausanne, Suisse;1. The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX;2. Department of Radiation Physics, The University of Texas MD Anderson Cancer, Houston, TX;3. Department of Radiation Oncology, The University of Texas MD Anderson Cancer, Houston, TX;4. The University of North Carolina at Chapel Hill, Chapel Hill, NC;5. Radiation Oncology, Christiana Care Health System, Newark, DE;1. National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan;2. Chiba University, 1-33 Yayoicho, Inage-ku, Chiba 263-8522, Japan;1. Jožef Stefan Institute, Ljubljana, Slovenia;2. Faculty of Chemistry and Chemical Engineering, University of Maribor, Maribor, Slovenia;3. Faculty of Mathematics and Physics, University of Ljubljana, Ljubljana, Slovenia;4. Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia;1. Département universitaire de radiothérapie et curiethérapie, centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59000 Lille, France;2. Département d’oncologie radiothérapie, institut Gustave-Roussy, 114, rue Édouard-Vaillant, 94805 Villejuif, France;3. Pôle de radiothérapie oncologique, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France;4. Service d’oncologie radiothérapie, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69395 Pierre-Bénite, France;5. Unité de curiethérapie, oncologie radiothérapie, pôle régional de cancérologie, CHU, 2, rue de la Milétrie, 86021 Poitiers, France;1. Nanomedicine Science and Technology Center, Northeastern University, Boston, Massachusetts;3. Department of Electrical and Computer Engineering, Northeastern University, Boston, Massachusetts;2. Department of Radiation Oncology, Brigham and Women''s Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts |
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| Abstract: | Standardized uptake values (SUV) are widely used in positron emission tomography (PET) to quantify 18F]2-fluoro-2-deoxy-d-glucose (18F-FDG) uptake, particularly in therapeutic follow-up. However, this index depends on many factors, be they methodological or biological, and its use is still a subject of debate. In this context, it is fundamental to establish a regular quality control to ensure quantitative indices constancy. In this perspective, a specific phantom with different size cylinder-shaped inserts was developed. The purpose of this study is to show the sensitivity and the interest of this phantom.MethodsThe phantom sensitivity was studied through SUV and recovery coefficient (RC) measurements. Several data analysis methods based on region of interest definition (ROI) were used. Data were reconstructed using clinical routine algorithms. We studied RC variation using cylinders with relative change of size and uptake (simulating treatment response) for different tumor-to-background activity ratio (TBR). Subsequently, the phantom was tested on another PET scanner.ResultsFor all data analysis methods, a considerable RC variation, of about 50%, was found with cylinder size. Measurement methods based on isocontours showed a strong correlation. This phantom also allowed to measure a relative uptake change which turned out to be independent of the measurement method. Despite calibration of the PET/CT systems, quantification differences of about 20% remained between the two centers studied.ConclusionThe results obtained show the interest of this phantom in the framework of following-up quantitative measurements in a given institution, or of an intercomparison in multicenter studies. |
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