近交系NJS小鼠的育种及其特性研究

近交系NJS小鼠是通过连续全同胞交配和在固定的普通日粮下以70日龄血清胆固醇含量为选育指标定向选育而成,经多项遗传监测证实已符合近交系动物的纯度要求,并具有独特的遗传概貌和特性。近交20世代后,该品系血清胆固醇含量为5.65±0.83mmol/L, 已超过小鼠的正常值范围,显示该品系小鼠已呈自发性高胆固醇血症状态。该品系8-10月龄动脉硬化在好发部位,如主动脉窦、升主动脉的阳性检出率为100%,主要是处于脂斑和脂纹期的病变。该品系可作为自发性高胆固醇血症和动脉粥样硬化症的模型动物。 Abstract:Inbred NJS mouse strain was bred by using continuous brother-sister mating and directive breeding on the common diet with serum cholesterol at 70 days as breeding index,Acording to various genetic monitoring,the strain has been bred as a standard inbred strain of mice in genetic homogeneity,with particular genetic system and specific property.After 20th generation,serum cholesterol of the strain was 5.65±0.83 mmol/L.This value went outside the normal range in mice showing that the strain was in a situation of spontaneous hypercholesterolemia.Its incidence of atheroscerosis was 100% in some liable positions such as aortic sac and ascending aorta at 8~10 months.Most of the pathological changes were in fatty streaks.The strain may be used as a animal model of spontaneous hypercholesterolemia and atherosclerosis.