Inhibition of dihydropteridine reductase by dopamine |
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| Authors: | Sheila E. Purdy John A. Blair Patricia A. Barford |
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| Affiliation: | Department of Chemistry, University of Aston in Birmingham, Gosta Green, Birmingham B4 7ET, U.K. |
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| Abstract: | Dihydropteridine reductase has been purified 900-fold from rat liver. Dopamine inhibited the enzyme up to 50% at a concentration of 0.11mm. In the presence of dopamine the enzyme gave non-hyperbolic v-against-[S] plots. This enzyme may have a role in control of dopamine biosynthesis. |
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