G2 Sub-Population In Mouse Liver Induced Into Mitosis By Lead Acetate |
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| Authors: | D. D. Choie G. W. Richter |
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| Affiliation: | Department of Pathology, the University of Rochester, School of Medicine and Dentistry, Rochester, New York, U.S.A. |
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| Abstract: | A single intracardiac dose of lead acetate (40 μ lead/g body weight) induced a 25-fold increase in mitosis of mouse hepatocytes 5 hr after injection, as determined by autoradiography. the prompt appearance of a mitotic wave and the relatively large number of mitoses suggest that the mitotic cells were derived from a hepatocyte sub-population arrested in the G2 phase. the injection of lead also stimulated a small increase in labeled hepatocytes within 6 hr. Analysis of grain counts gave no evidence for unscheduled DNA synthesis. the incremental labeled cells may have originated from a small fraction of the G1 population that was ready to enter the S phase without the usual pre-synthetic delay. |
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