Centromere proteins |
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Authors: | Gyula Hadlaczky Tunde Praznovszky Istvan Rasko Judit Kereso |
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Institution: | (1) Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, H-6701 Szeged, Hungary |
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Abstract: | Human anti-centromere sera from scleroderma patients were used to detect centromere antigens of mouse fibroblast cells. An Mr=59000 centromere protein was localized exclusively on mitotic chromosomes. The association of this protein with the mitotic chromosomes proved to be DNase I sensitive. In interphase nuclei, this centromere antigen was not detectable by immunoblot techniques. The results suggest that the Mr=59000 mitosis specific protein may be necessary for the structural stability of kinetochores during mitosis. |
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