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Areas of Monounsaturated Diacylphosphatidylcholines |
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| Authors: | Norbert Ku?erka Jana Gallová Daniela Uhríková Pavol Balgavy Monica Bulacu Siewert-Jan Marrink John Katsaras |
| Institution: | † Canadian Neutron Beam Centre, National Research Council, Chalk River, Ontario, Canada ‡ Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia § Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands ¶ Department of Physics, Brock University, St. Catharines, Ontario, Canada ‖ Guelph-Waterloo Physics Institute and Biophysics Interdepartmental Group, University of Guelph, Guelph, Ontario, Canada |
| Abstract: | We have studied the structural properties of monounsaturated diacylphosphatidylcholine lipid bilayers (i.e., diCn:1PC, where n = 14, 16, 18, 20, 22, and 24 is the number of acyl chain carbons). High-resolution x-ray scattering data were analyzed in conjunction with contrast-varied neutron scattering data using a technique we recently developed. Analyses of the data show that the manner by which bilayer thickness increases with increasing n in monounsaturated diacylphosphatidylcholines is dependent on the double bond's position. For commonly available monounsaturated diacylphosphatidylcholines, this results in the nonlinear behavior of both bilayer thickness and lipid area, whereas for diC18:1PC bilayers, lipid area assumes a maximum value. It is worthwhile to note that compared to previous data, our results indicate that lipid areas are smaller by ∼10%. This observation highlights the need to revisit lipid areas, as they are often used in comparisons with molecular dynamics simulations. Moreover, simulators are encouraged to compare their results not only to x-ray scattering data, but to neutron data as well. |
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