How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures |
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| Authors: | Mullins R D |
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| Affiliation: | Department of Cellular and Molecular Pharmacology, University of California Medical School, San Francisco, CA 94129, USA. dyche@itsa. ucsf.edu |
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| Abstract: | In most cells, the structure of the actin cytoskeleton is regulated by Rho-family G proteins. Recent work has outlined a highly conserved signaling pathway from G protein activation to actin assembly. The key downstream components are WASP family proteins - adaptor molecules that bind multiple signaling and cytoskeletal proteins - and the Arp2/3 complex - a multi-functional protein complex that nucleates and crosslinks actin filaments. |
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