Human Herpesvirus 6 Latently Infects Early Bone Marrow Progenitors In Vivo |
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| Authors: | Mario Luppi Patrizia Barozzi Christine Morris Antonio Maiorana Richard Garber Goretta Bonacorsi Amedea Donelli Roberto Marasca Antonio Tabilio and Giuseppe Torelli |
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| Institution: | Section of Hematology, Department of Medical Sciences,1. and Department of Pathology,3. University of Modena, Modena, and Clinical Hematology and Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia,5. Italy; Cytogenetic and Molecular Oncology Unit, Department of Pathology, Christchurch School of Medicine, Christchurch, New Zealand2.; and PathoGenesis Corporation, Seattle, Washington4. |
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| Abstract: | We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for hemopoietic cells in patients with latent HHV-6 infection. Having used a variety of cell purification, molecular, cytogenetic, and immunocytochemical procedures, we report the first evidence that HHV-6 latently infects early bone marrow progenitor cells and that HHV-6 may be transmitted longitudinally to cells which differentiate along the committed pathways. |
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