Hyperosmotic instillation of rat stomach. |
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| Authors: | T J Sernka A F Jackson |
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| Institution: | Department of Physiology and Biophysics Louisiana State University Medical Center School of Medicine in Shreveport Shreveport, Louisiana 71130, USA |
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| Abstract: | Instillation of equally hyperosmotic solutions (1000 m0sm/kg) of NaCl, KCl, MgCl2, or dextrose depressed the electrical potential difference and the spontaneous acid secretion of rat stomachs. Luminal osmolality declined only slightly after hyperosmotic dextrose instillation, but loss of luminal chloride followed hyperosmotic salt instillation. Comparable losses of luminal sodium or potassium were observed. These changes result from a hyperosmotic alteration of ion transport through the gastric mucosa. |
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