Changes in Activity of Choline Acetylase in Central Nervous System of Rat after Intraventricular Administration of Noradrenaline |
| |
Authors: | GEORGE SINGER ANDREW HO SAMUEL GERSHON |
| |
Institution: | 1.MRC Neuropsychiatry Unit, MRC Laboratories,Carshalton, Surrey;2.Department of Pharmacology,Maulana Azad Medical College,New Delhi |
| |
Abstract: | APPLICATION of strychnine or d-tubocurarine to the exposed cerebral cortex leads after a few minutes to abnormality in somatosensory evoked potentials1,2. This consists of a surface negative wave (peak latency, 21–23 ms) which attains an amplitude five to twenty times greater than that of the normal evoked potentials and probably reflects excessive depolarization of the apical dendrites of pyramidal neurones. We wish to report the blocking of this effect by prior application of eserine to the cortex. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|