The teichoic acid (C-polysaccharide) synthesized by Streptococcus pneumoniae serotype 5 has a specific structure |
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Authors: | Vialle Sandrine Sepulcri Patricia Dubayle Jean Talaga Philippe |
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Affiliation: | Aventis Pasteur, Campus Mérieux, Biochemistry Research Department, 1541 Avenue Marcel Mérieux, F-69280 Marcy l' Etoile, France. |
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Abstract: | The teichoic acid synthesized by Streptococcus pneumoniae serotype 5, also known as pneumococcal common antigen (C-polysaccharide), was purified. On the basis of compositional analysis, HPAEC-PAD analysis, MALDI-TOF mass spectrometry and NMR spectroscopy, made on the native polysaccharide and on the dephosphorylated repeating unit, the following structure is proposed: [structure: see text]. This C-polysaccharide (C-PS), differs from those previously described by the replacement of Glc by Gal in its repeating unit structure. |
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Keywords: | Streptococcus pneumoniae Serotype 5 Teichoic acid C-polysaccharide Pneumococcal capsular polysaccharides Pneumococcal vaccine |
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