| Abstract: | Se-Aryl selenenylthiosulphates and S-aryl sulphenylthiosulphates inhibit papain at pH 5.8 much more rapidly than do the corresponding Se-aryl selenosulphates and S-aryl thiosulphates, and also more rapidly than do Se-alkyl selenosulphates. Se-p-Nitrophenyl selenenylthiosulphate and S-p-nitrophenyl sulphenylthiosulphate inactivate papain most rapidly, but the inactivation is slowly and spontaneously reversible. Inactivation by Se-o-nitrophenyl selenenylthiosulphate and S-o-nitrophenyl sulphenylthiosulphate, although less rapid than that by the para isomers, is essentially irreversible. |
