'Small' talk: Opa proteins as mediators of Neisseria-host-cell communication |
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Authors: | Hauck Christof R Meyer Thomas F |
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Affiliation: | Zentrum für Infektionsforschung, Universit?t Würzburg, Würzburg, Germany. |
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Abstract: | Opa proteins are variable outer membrane proteins of Neisseria gonorrhoeae and Neisseria meningitidis that mediate tight interaction of these pathogens with human cells. They have emerged as a paradigm of a bacterial toolbox allowing recognition of different host receptors and orchestrating the cell type tropism displayed by pathogenic Neisseriae. Recent work has highlighted the molecular basis of Opa-protein-host-receptor interaction and has shed new light on the functional consequences of this interaction with regard to bacterial attachment, invasion, and responses elicited in particular host cells. |
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