Localization of neuropeptide Y and atrial natriuretic peptide in the endothelial cells of human umibilical blood vessels |
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| Authors: | W Q Cai P Bodin A Sexton A Loesch G Burnstock |
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| Institution: | (1) Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT London, United Kingdom;(2) Centre for Neuroscience, University College London, Gower Street, WC1E 6BT London, United Kingdom |
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| Abstract: | The localization of neuropeptide Y (NPY) and atrial natriuretic peptide (ANP) in the endothelial cells of human umbilical blood vessels was studied using the pre-embedding peroxidase-antiperoxidase (PAP) technique for electron microscopy and avidin-biotin-complex (ABC) immunostaining for endothelial cells cultured from umbilical vein. Subpopulations of NPY- and ANP-immunoreactive endothelial cells were present in term umbilical vein and artery. The umbilical vein contained more positive cells than the artery. The percentage of NPY- and ANP-immunoreactive umbilical vein cells in culture was 32% and 44%, respectively, out of a total of 3013 cells examined. The possibility that these potent vasoactive substances located in the endothelial cells of the non-innervated umbilical vessels are involved in the local regulation of blood flow is discussed. |
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| Keywords: | Neuropeptide Y Atrial natriuretic peptide Endothelial cells Umbilical blood vessels Human |
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