| 雨蛙肽中枢促胃酸分泌作用机制的初步分析 |
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| 引用本文： | 屠亚红,朱文玉.雨蛙肽中枢促胃酸分泌作用机制的初步分析[J].生理学报,1984(6). |
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| 作者姓名： | 屠亚红 朱文玉 |
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| 作者单位： | 北京医学院基础医学研究所消化研究室
(屠亚红)，北京医学院基础医学研究所生殖生理研究室(朱文玉) |
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| 摘 要： | 利用特异的受体阻断剂能够拮抗相应的受体激动剂的效应的原理,分析雨蛙肽中枢促胃酸分泌作用的受体机制。向大鼠侧脑室内注射微量雨蛙肽(67ng/鼠),可引起急性灌流大鼠胃酸分泌明显增加。预先向大鼠侧脑室内注射肾上腺素受体阻断剂酚妥拉明或心得安,20min后再向侧脑室内注射雨蛙肽,预处理对雨蛙肽的促胃酸分泌作用影响不大。但事先向侧脑室内注射乙酰胆碱受体阻断剂阿托品或胆囊收缩素(CCK)受体阻断剂二丁酰环化-磷酸鸟苷(Bt_2 cGMP)则可有效地阻断雨蛙肽的作用。以上结果提示,脑内雨蛙肽促胃酸分泌机制中,可能有 CCK 受体和胆碱能受体参与,而与肾上腺素能系统关系不大。
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| 关 键 词： | 雨蛙肽 侧脑室内注射 心安得 酚妥拉明 阿托品 二丁酰环-磷酸鸟苷 |
STUDY ON THE MECHANISM OF GASTRIC ACID SECRETION INDUCED BY CENTRAL CAERULEIN |
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| TU YA-HONG,ZHU WEN-YU.STUDY ON THE MECHANISM OF GASTRIC ACID SECRETION INDUCED BY CENTRAL CAERULEIN[J].Acta Physiologica Sinica,1984(6). |
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| Authors: | TU YA-HONG ZHU WEN-YU |
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| Abstract: | The central mechanism of gastric acid secretion induced by intracerebro-ven-tricular(icv)injection of caerulein was studied by the effect of similarly applied va-rious receptor antagonists 20 min prior to caerulein.Techniques of continuousgastric perfusion of Ghosh and Schild and cerebral cannula implantation were usedfor acute experiments in rats.Pcrfusates collected every 10 min were titrated toquantify the total acid output.Icv injection of caerulein significantly stimulated gastric acid secretion.Prioricv administration of phentolamine or propranolol did not influence the effect ofcaerulein,but the acid output induced by caerulein was completely abolished aftera prior injection of atropine or dibutyryl cGMP(CCK-receptor antagonist).It seems that CCK receptor and cholinergic receptor in brain are involved inthe mechanisms of gastric acid secretion induced by caerulein. |
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| Keywords: | caerulein intracerebro-ventricular injection propranolol phentolamine atropine dibutyryl cyclic guanosine monophosphate |
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