Solid-phase synthesis of pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones |
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| Authors: | Kamal A Reddy G S Raghavan S |
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| Institution: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad, India. ahmedkamal@iict.ap.nic.in |
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| Abstract: | The solid-phase synthesis of biologically important pyrrolo2,1-c]1,4]benzodiazepine-5,11-diones using Wang resin through amide formation and reductive cyclization procedures is described. Further, N10-substituents have been introduced in the final products and these have been cleaved from the solid support in good yields. |
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