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Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440 |
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| Authors: | Nelson K E Weinel C Paulsen I T Dodson R J Hilbert H Martins dos Santos V A P Fouts D E Gill S R Pop M Holmes M Brinkac L Beanan M DeBoy R T Daugherty S Kolonay J Madupu R Nelson W White O Peterson J Khouri H Hance I Chris Lee P Holtzapple E Scanlan D Tran K Moazzez A Utterback T Rizzo M Lee K Kosack D Moestl D Wedler H Lauber J Stjepandic D Hoheisel J Straetz M Heim S Kiewitz C Eisen J A Timmis K N Düsterhöft A Tümmler B Fraser C M |
| Affiliation: | The Institute for Genomic Research (TIGR), 9712 Medical Center Drive, Rockville, MD 20850, USA.;Klinische Forschergruppe, OE 6711, Medizinische Hochschule Hannover (MHH), Hannover, Germany.;Qiagen GmbH, Hilden, Germany.;Gesellschaft für Biotechnologische Forschung (GBF), Braunschweig, Germany.;Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany. |
| Abstract: | Pseudomonas putida is a metabolically versatile saprophytic soil bacterium that has been certified as a biosafety host for the cloning of foreign genes. The bacterium also has considerable potential for biotechnological applications. Sequence analysis of the 6.18 Mb genome of strain KT2440 reveals diverse transport and metabolic systems. Although there is a high level of genome conservation with the pathogenic Pseudomonad Pseudomonas aeruginosa (85% of the predicted coding regions are shared), key virulence factors including exotoxin A and type III secretion systems are absent. Analysis of the genome gives insight into the non-pathogenic nature of P. putida and points to potential new applications in agriculture, biocatalysis, bioremediation and bioplastic production. |
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