Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans |
| |
| Authors: | Rubin S A Pletnikov M Taffs R Snoy P J Kobasa D Brown E G Wright K E Carbone K M |
| |
| Affiliation: | Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. rubins@cber.fda.gov |
| |
| Abstract: | Neurovirulence of several mumps virus strains was assessed in a prototype rat neurovirulence test and compared to results obtained in the monkey neurovirulence test. The relative human neurovirulence of these strains was proportional to the severity of hydrocephalus in rats but not to lesion scores in the monkeys. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
