cDNA cloning of the beta-subunit of the human gastric H,K-ATPase. |
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| Authors: | J Y Ma Y H Song S E Sj?strand L Rask S M?rdh |
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| Institution: | Department of Medical and Physiological Chemistry, Biomedical Centre, Uppsala, Sweden. |
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| Abstract: | A full-length cDNA clone encoding the human gastric H,K-ATPase (EC 3.6.1.36)beta-subunit was isolated from a human gastric mucosal lambda gt10 library using oligonucleotide probes which were based on the cDNA sequence from rat and rabbit H,K-ATPase beta-subunits. The insert was 1407 bp in length and encoded a polypeptide of 291 amino acids with a MW = 33,367 Da. It exhibited 84.2%, 85.6% and 81.3% identity to the H,K-ATPase beta-subunits of rabbit, pig and rat, respectively. |
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