Gene expression variation in Down's syndrome mice allows prioritization of candidate genes |
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| Authors: | Marc Sultan Ilaria Piccini Daniela Balzereit Ralf Herwig Nidhi G Saran Hans Lehrach Roger H Reeves Marie-Laure Yaspo |
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| Affiliation: | (1) Max Planck Institute for Molecular Genetics, Ihnestr.63/73, 14195 Berlin, Germany;(2) Department of Physiology, Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, Maryland 21205, USA;(3) McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 Nth. Broadway, Baltimore, Maryland 21205, USA |
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| Abstract: | Background Down's syndrome (DS), or trisomy 21, is a complex developmental disorder that exhibits many clinical signs that vary in occurrence and severity among patients. The molecular mechanisms responsible for DS have thus far remained elusive. We argue here that normal variation in gene expression in the population contributes to the heterogeneous clinical picture of DS, and we estimated the amplitude of this variation in 50 mouse orthologs of chromosome 21 genes in brain regions of Ts65Dn (a mouse model of DS). We analyzed the RNAs of eight Ts65Dn and eight euploid mice by real-time polymerase chain reaction. |
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