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Structural investigations into the binding mode of a novel noscapine analogue, 9-(4-vinylphenyl) noscapine,with tubulin by biochemical analyses and molecular dynamic simulations |
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| Authors: | Tejashree Mahaddalkar Pradeep Kumar Naik Sinjan Choudhary Naresh Manchukonda Srinivas Kantevari |
| Institution: | 1. Experimental Cancer Therapeutics and Chemical Biology, UM-DAE Centre for Excellence in Basic Sciences, University of Mumbai Kalina Campus, Santacruz (E), Mumbai 400098, India;2. Department of Biotechnology, Guru Ghasidas Central University, Bilaspur, Chattisgarh 495009, India;3. Organic Chemistry Division-II (CPC Division), CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana 500007, India |
| Abstract: | |
| Keywords: | microtubules molecular dynamic simulations tubulin isotypes βIII tubulin noscapine 9-(4-vinylphenyl) noscapine |