Modification of the Membrane Components of Synaptosomes and the Fusion Process |
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| Authors: | V Tsyvkin I Prudnikov T Kastrykina L Kolchinskaya M Malysheva |
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| Institution: | (1) Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine |
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| Abstract: | A model system consisting of synaptic vesicles and synaptic membrane fragments isolated from brain synaptosomes was used for studying the role of the state of membrane components in membrane fusion. It is concluded that the state of proteins and lipids of biological membranes influences considerably the membrane's ability to fuse. This state can be changed by the regulation of cell enzyme systems (proteolytic enzymes, phospholipases), and regulation by nitric oxide is an important aspect of this control. |
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| Keywords: | exocytosis fusion synaptosomes membrane modification nitric oxide |
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