Reduction in the mechanonociceptive response by intrathecal administration of glycine and related compounds |
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Authors: | Richard K Simpson Jr Margaret Gondo Claudia S Robertson J Clay Goodman |
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Institution: | (1) Department of Neurosurgery, Baylor College of Medicine, One Baylor Plaza, 77030 Houston, Texas;(2) Department of Pathology, Baylor College of Medicine, One Baylor Plaza, 77030 Houston, Texas |
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Abstract: | We have previously reported that enhanced glycine release is produced by epidural spinal cord stimulation, a clinical method
for treating neuropathic pain. Our current hypothesis is that glycine administered intrathecally reduces neuropathic pain
as measured by the Randall-Selitto method. Neuropathic rats created by unilateral partial ligation of the sciatic nerve were
treated with intrathecal infusion of glycine, strychnine, MK-801, or 5,7-DKA at 0.1 μmol, or artificial CSF for 2 hours at
a rate of 10 μl/min. Force required to produce the pain response was significantly increased after glycine administration
and reduced using strychnine, a specific glycine receptor (Gly 1) antagonist. Strychnine blocked the response to glycine when
infused together. Administration of the non-specific NMDA receptor MK-801 antagonist and 5,7-DKA, a specific glycine-NMDA
receptor (Gly 2) antagonist, however, failed to block the response to glycine. Our results provide evidence for the use of
glycine and related compounds to treat neuropathic pain. |
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Keywords: | Glycine neuropathic pain |
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