Effect of hydroxyurea on procyclic Trypanosoma brucei: an unconventional mechanism for achieving synchronous growth |
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| Authors: | Chowdhury Arnab Roy Zhao Zhixing Englund Paul T |
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| Affiliation: | Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. |
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| Abstract: | Procyclic Trypanosoma brucei cells were synchronized with 0.2 mM hydroxyurea. The cells did not arrest at the G1/S boundary but proceeded through one round of replication and arrested near the end of S phase. The mitochondrial genome (kinetoplast DNA network) replicated, forming two progeny networks, but the repair of minicircle gaps was inhibited. |
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