Blocking of cholecystokinin octapeptide behavioral effects by proglumide |
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Authors: | G Katsuura S Hsiao S Itoh |
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Institution: | 1. Shionogi Research Laboratories, Fukushima-ku, Osaka 553, Japan;2. Department of Psychology, University of Arizona, Tucson, AZ 85721, USA |
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Abstract: | An open field apparatus was used to assess the effect of proglumide, a selective antagonist of cholecystokinin octapeptide (CCK-8), to block the behavioral effect of CCK-8 in rats. Intracerebroventricular (ICV) injection of CCK-8 (0.5 to 2 micrograms) was effective in suppressing general exploratory activities and this effect was blocked by proglumide at doses of 2 to 5 micrograms administered ICV or 1 mg/kg administered subcutaneously. The effect of peripherally administered CCK-8 (10 micrograms/kg) was blocked by peripherally administered proglumide at a dose of 2 mg/kg but not by centrally administered proglumide at a dose of 5 micrograms/rat. The behavioral effect of CCK-8 was thus clearly blocked by proglumide. |
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Keywords: | Cholecystokinin octapeptide Proglumide Anti-CCK-8 compound General activity |
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