Cellular and systemic effects of anthrax lethal toxin and edema toxin |
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| Authors: | Mahtab Moayeri Stephen H. Leppla |
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| Affiliation: | 1. Dept. of Biomedical SciencesUniversità di Padova, Via Trieste, 75 Padova, I-35121, Italy (Ph: +39 049 827 6058);2. Toxines et Pathogénies Bactériennes, Institut Pasteur, 28 Rue du Dr Roux, 75724-PARIS cedex 15, France |
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| Abstract: | Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and can replicate the lethality and symptoms associated with the disease. This review provides an overview of our current understanding of anthrax toxin effects in animal models and the cytotoxicity (necrosis and apoptosis) induced by LT in different cells. A brief reexamination of early historic findings on toxin in vivo effects in the context of our current knowledge is also presented. |
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