Receptors of anthrax toxin and cell entry |
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| Authors: | Gisou van der Goot John A.T. Young |
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| Affiliation: | 1. Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, SV-AI Extension, Station 15, 1015 Lausanne, Switzerland;2. Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, United States;1. Dept. of Biomedical SciencesUniversità di Padova, Via Trieste, 75 Padova, I-35121, Italy (Ph: +39 049 827 6058);2. Toxines et Pathogénies Bactériennes, Institut Pasteur, 28 Rue du Dr Roux, 75724-PARIS cedex 15, France |
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| Abstract: | Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cellular receptors, and how receptor-type can dictate the low pH threshold of PA pore formation. The roles played by cellular factors in regulating the endocytosis of toxin-receptor complexes is also discussed. |
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