Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants |
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Authors: | Jörg Degenhardt Tobias G. Köllner Jonathan Gershenzon |
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Affiliation: | 1. Martin Luther University Halle-Wittenberg, Institute for Pharmacy, Hoher Weg 8, D-06120 Halle/Saale, Germany;2. Max Planck Institute for Chemical Ecology, Hans-Knöll Strasse 8, D-07745 Jena, Germany |
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Abstract: | The multitude of terpene carbon skeletons in plants is formed by enzymes known as terpene synthases. This review covers the monoterpene and sesquiterpene synthases presenting an up-to-date list of enzymes reported and evidence for their ability to form multiple products. The reaction mechanisms of these enzyme classes are described, and information on how terpene synthase proteins mediate catalysis is summarized. Correlations between specific amino acid motifs and terpene synthase function are described, including an analysis of the relationships between active site sequence and cyclization type and a discussion of whether specific protein features might facilitate multiple product formation. |
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