Free calcium rise and mitogenesis in glial cells caused by endothelin |
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| Authors: | S Supattapone A W Simpson C C Ashley |
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| Affiliation: | University Laboratory of Physiology, Oxford, U.K. |
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| Abstract: | The peptide endothelin causes a biphasic rise in intracellular free calcium levels in cultured Type-1 astrocytes and C6 glioma cells, suggesting that glial cells may be the physiological target of endothelin in the brain. Endothelin also causes a calcium-dependent increase [3H]thymidine incorporation in primary cultures of rat cerebellum, indicating that, among other possible roles, this peptide may mediate mitogenesis in brain. |
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