gammadelta T cells in malaria infections |
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Authors: | Langhorne J |
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Affiliation: | Infection and Immunity Section in the Department of Biology, Imperial College of Science, Technology and Medicine, Prince Consort Rd London, UK. j.langhorne@ic.ac.uk |
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Abstract: | The association of a pronounced gammadelta T-cell response with Plasmodium infections is intriguing. The ability of parasite material to activate gammadelta T cells in vitro, and the localization of these cells in vivo in the red pulp of the spleen, suggests that these cells could play a role in the killing of bloodstage malaria parasites. However, the magnitude, the response and the predominance of inflammatory cytokines secreted by these cells may also indicate a role in the pathology of malaria infections. In this article, Jean Langhorne reveiws the current status of gammadelta T cells in malaria in the context of what is known about the function and specificity of gammadelta T cells in general. |
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