Carnitine synthesis in rat tissue slices |
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Authors: | H T Haigler H P Broquist |
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Institution: | Division of Nutrition, Department of Biochemistry Vanderbilt University School of Medicine Nashville, Tennessee 37232 USA |
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Abstract: | The ability of rat liver, kidney, muscle, heart and testis tissue to carry out the synthesis of carnitine via ε-N-trimethyllysine and γ-butyrobetaine was studied. All tissues formed γ-butyrobetaine from trimethyllysine, but liver and testis also formed carnitine in about 7% and 1% yield respectively. Liver slices formed trimethyllysine from lysine in about 6% yield. These studies thus establish that liver has all the enzymes of the carnitine biosynthetic pathway. This tissue appears to be the primary site of carnitine synthesis in the rat as implied from whole animal studies in this and other laboratories. |
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