Complete amino acid sequence of a unique protein related to the variable domain of lambda light chain from a case with Fanconi syndrome |
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Authors: | F Kametani K Yoshimura H Tonoike A Hoshi T Shinoda T Isobe |
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Affiliation: | 1. Faculty of Sciences and Technology, Universidade Nova de Lisboa, Department of Mechanical and Industrial Engineering, Campus de Caparica, 2829-516 Caparica, Portugal;2. UNIDEMI, Faculty of Sciences and Technology, Universidade Nova de Lisboa, Department of Mechanical and Industrial Engineering, Campus de Caparica, 2829-516 Caparica, Portugal;3. Centralcer, Maintenance Department, Central de Cervejas, S.A., Vialonga, Portugal |
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Abstract: | The complete amino acid sequence has been determined of a unique protein from a 55-years-old female with multiple myeloma associated with Fanconi syndrome. It existed in a monomer form with an apparent molecular weight of 10K daltons, and was consisted of 106 amino acid residues. The sequence was characteristic of the V-region of lambda light chains and was highly homologous with that of the first 106 residues of V lambda III subgroup. The presence of an intact light chain as well as a 13K daltons fragment, corresponding to the entire C-region, strongly suggests that the unique component is a catabolic product from the intact light chain rather than an aberrant product of synthesis. |
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