DNA methylation analysis reveals the effect of arsenic on gestational diabetes mellitus |
| |
| Institution: | 1. Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China;2. Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan 030001, China;3. Department of Endocrinology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China;4. Department of Obstetrics, The First Hospital of Shanxi Medical University, Taiyuan 030001, China;5. National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China |
| |
| Abstract: | BackgroundArsenic (As) exposure is one of the risk factors for gestational diabetes mellitus (GDM). This study aimed to explore the effect of As-exposure on DNA methylation in GDM and to establish a risk assessment model of GDM in As exposed pregnant women.MethodWe collected elbow vein blood of pregnant women before delivery to measure As concentration and DNA methylation data. Then compared the DNA methylation data and established a nomogram.ResultWe identified a total of 10 key differentially methylated CpGs (DMCs) and found 6 corresponding genes. Functions were enriched in Hippo signaling pathway, cell tight junction, prophetic acid metabolism, ketone body metabolic process, and antigen processing and presentation. A nomogram was established that can predict GDM risks (c-index = 0.595, s:p = 0.973).ConclusionWe found 6 genes associated with GDM with high As exposure. The prediction of the nomograms has been proven to be effective. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
