Identifying the role of hypoxia-related lncRNAs in pancreatic cancer |
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| Affiliation: | 1. Department of Pancreatic Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China;2. Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China;3. The Stomatology Center of Xiangya Hospital, Central South University, Changsha 410008, Hunan, China;4. Academician workstation for Oral & Maxillofacial Regenerative Medicine, Central South University, Changsha 410008, Hunan, China;5. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China |
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| Abstract: | BackgroundLong noncoding RNAs (lncRNAs) play important roles in hypoxia-induced tumor processes. However, the prognostic value of hypoxia-related lncRNAs in pancreatic cancer is limited.MethodsHypoxia-related lncRNAs were identified by coexpression analysis and the LncTarD database. LASSO analysis was performed to develop a prognostic model. The function of TSPOAP1-AS1 was studied in vitro and in vivo.ResultsWe recognized a set of fourteen hypoxia-related lncRNAs for the construction of a prognostic model. The prognostic model displayed excellent performance in predicting the prognosis of pancreatic cancer patients. The overexpression of TSPOAP1-AS1, a hypoxia-related lncRNA, attenuated the proliferation and invasion of pancreatic cancer cells. HIF-1α bound to the promoter of TSPOAP1-AS1 and impaired its transcription under hypoxia.ConclusionThe hypoxia-related lncRNA assessment model might be a potential strategy for prognostic prediction in pancreatic cancer. The fourteen lncRNAs contained in the model could be helpful for uncovering the mechanisms of pancreatic tumorigenesis. |
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