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Evaluating anti-Orthopoxvirus antibodies in individuals from Brazilian rural areas prior to the bovine vaccinia era |
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| Authors: | Poliana de Oliveira Figueiredo André Tavares da Silva-Fernandes Bruno Eduardo Fernandes Mota Galileu Barbosa Costa Iara Apolinário Borges Paulo César Peregrino Ferreira J?natas Santos Abrah?o Erika Martins Braga Erna Geessien Kroon Giliane de Souza Trindade |
| Affiliation: | 1.Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Vírus, Belo Horizonte, MG, Brasil;2.Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Parasitologia, Laboratório de Malária, Belo Horizonte, MG, Brasil |
| Abstract: | Vaccinia virus naturally circulates in Brazil and is the causative agent of azoonotic disease known as bovine vaccinia (BV). We retrospectively evaluated twopopulations from the Amazon and Southeast Regions. BV outbreaks had not been reportedin these regions before sample collection. Neutralising antibodies were found in 13individuals (n = 132) with titres ranging from 100 ≥ 6,400 neutralising units/mL.Univariate analysis identified age and vaccination as statistically significant riskfactors in individuals from the Southeast Region. The absence of detectableantibodies in vaccinated individuals raises questions about the protection ofsmallpox vaccine years after vaccination and reinforces the need for surveillance ofOrthopoxvirus in Brazilian populations without evidence of previous outbreaks. |
| Keywords: | Orthopoxvirus smallpox vaccine bovine vaccinia retrospective serosurvey |