Clinicopathological Characteristics and Survival Outcomes of Primary Signet Ring Cell Carcinoma in the Stomach: Retrospective Analysis of Single Center Database |
| |
Authors: | Xiaowen Liu Hong Cai Weiqi Sheng Lin Yu Ziwen Long Yingqiang Shi Yanong Wang |
| |
Institution: | 1. Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; 2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.; 3. Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Duke Cancer Institute, UNITED STATES, |
| |
Abstract: | PurposeTo investigate the clinicopathological features and prognosis of signet ring cell carcinoma of the stomach (SRC).MethodsA total of 1464 gastric cancer patients who underwent curative gastrectomy from 2000 to 2008 at a single center were evaluated. Signet ring cell carcinoma (SRC) was defined as the presence of at least 50% signet ring cells in the pathologic specimen. The clinicopathological parameters and prognosis of SRC were analyzed by comparing with non-signet ring cell carcinoma (NSRC).ResultsOf 1464 patients, 138 patients (9.4%) were classified as SRC. There were significant differences in gender, age, tumor location, TNM stage, p21 expression, and p53 expression between SRC and NSRC. The 5-year survival rates of SRC and NSRC were 36.2% and 49.5%, respectively. The prognosis of SRC was poorer than that of NSRC (P <0.001). Multivariate analysis showed that SRC histology was an independent factor for poor prognosis (P <0.001).ConclusionPatients with SRC tend to present with a more advanced stage and poorer prognosis than patients with other types of gastric carcinoma. |
| |
Keywords: | |
|
|